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The 80-125% Rule: How Bioequivalence Confidence Intervals Ensure Generic Drugs Work the Same
Jan 27, 2026 Rob Elliott

The 80-125% Rule: How Bioequivalence Confidence Intervals Ensure Generic Drugs Work the Same

The 80-125% rule ensures generic drugs perform like brand-name versions by measuring how much and how fast the body absorbs the active ingredient. It's based on pharmacokinetic data and a 90% confidence interval, not pill composition.

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